| 陈小蔓1
，张艺玮1
，宋恒博1
，李功捷1
，孙 丽1,2,3,4*.超顺磁性Fe3O4纳米颗粒的制备与表征[J].海南师范大学学报自科版,2025,38(2):177-182 |
| 超顺磁性Fe3O4纳米颗粒的制备与表征 |
| Preparation and Characterization of Superparamagnetic Fe3O4 Nanoparticles |
| |
| DOI：10.12051/j.issn.1674-4942.2025.02.008 |
| 中文关键词: Fe3O4 超顺磁 纳米颗粒，可逆百分比 |
| 英文关键词: Fe3O4 superparamagnetic nanoparticles reversible percentage |
| 基金项目:国 家 自 然 科 学 基 金（12164016）；海 南 省 自 然 科 学 基 金（521QN0885）；海 南 师 范 大 学 榕 树 基 金
（RSHY20231165810S、RSYH20231165820S）；海南省院士创新平台科研项目（YSPTZX202207） |
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| 中文摘要: |
| 超顺磁性、小尺寸四氧化三铁（Fe3O4
）纳米颗粒被广泛应用于磁共振、靶向药物载体等
生物医学领域以及磁自旋电子学领域。利用溶胶-凝胶法，以七水合硫酸亚铁（FeSO4•7H2O）作为
唯一铁源，氢氧化钾（KOH）提供碱性环境，通过改变反应物浓度和反应溶剂乙二醇溶液制备了平
均粒径在10 ~ 25 nm的Fe3O4纳米颗粒。使用X-射线衍射仪（XRD）、拉曼光谱仪（Raman）、透射电
子显微镜（TEM）、振动样品磁强计（VSM）等对不同颗粒尺寸的Fe3O4颗粒系统进行表征，得到了反
应物的浓度和反应溶剂的配比对Fe3O4纳米颗粒尺寸的影响，同时通过利用一阶反转曲线分析系统
的可逆百分比，进一步验证了平均颗粒尺寸较小的Fe3O4纳米颗粒系统具有更高的超顺磁比例。结
果表明，随着乙二醇比例的增加，颗粒先增大后减小，当V 水∶V 乙二醇=70∶30，制备的颗粒平均粒径约
为14 nm，说明一定比例的乙二醇阻碍颗粒长大；同时过量OH-
的加入，颗粒尺寸减小到10 nm。磁
性测量得出制备的Fe3O4纳米颗粒均具有较好的磁性；随着颗粒尺寸的增加，伴随着颗粒畴结构的
变化，矫顽力由几乎为零迅速增大到45 Oe（17 nm）和60 Oe （25 nm）；颗粒尺寸≤14 nm的颗粒系统，
高达96的平均可逆百分比验证了颗粒系统的高超顺磁比例。 |
| 英文摘要: |
| Small Magnetite (Fe₃O₄) nanoparticles with superparamagnetic properties are widely used in biomedical applica⁃
tions such as magnetic resonance and targeted drug carriers, as well as in magnetic spintronics. Using the sol-gel method
with ferrous sulfate heptahydrate (FeSO₄·7H₂O) as the sole iron source and potassium hydroxide (KOH) to provide an alkaline environment, Fe₃O₄ nanoparticles with an average particle size of 10-25 nm were prepared by varying the concentration of
the reactants and the reaction solvent (ethylene glycol solution). Fe₃O₄ particles were characterized using X-ray diffractometer
(XRD), Raman spectrometer (Raman), transmission electron microscope (TEM), vibrating sample magnetometer (VSM), etc.
The effects of the concentration of the reactants and the ratio of the reaction solvents on the size of the Fe ₃O₄ nanoparticles
were obtained, and the reversibility of the systems was also analyzed through the use of the first-order reversal curves. It was
verified that the Fe₃O₄ nanoparticle systems with smaller average particle sizes had higher superparamagnetic ratios. With the
increase of the proportion of ethylene glycol, the mean size of Fe ₃O₄ particles first increased and then decreased. When
V(H₂O):V(EG) = 70:30, the average particle size was about 14 nm, which indicated that a certain proportion of ethylene glycol
hindered the growth of the particles. At the same time, the particle size decreased to 10 nm with the addition of excess OH⁻.
With the increase of particle size, the coercivity increased rapidly from almost zero to 45 Oe at 17 nm and 60 Oe at 25 nm, ac⁃
companied by the change of the particle domain structure. The small coercivity and high average reversible percentage (96%)
of the particle systems with particle sizes less than or equal to 14 nm verified a high superparamagnetic percentage. |
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