| 周董董，陈丹丹，邓小林，冯 婷，徐 静*.靶向Wnt/β-catenin信号通路的抗肿瘤活性分子
研究进展[J].海南师范大学学报自科版,2023,36(2):223-229 |
| 靶向Wnt/β-catenin信号通路的抗肿瘤活性分子
研究进展 |
| Advances in Antitumor Molecules Inhibiting Wnt/β-catenin Signaling |
| |
| DOI：10.12051/j.issn.1674-4942.2023.02.017 |
| 中文关键词: Wnt/β-catenin信号通路 抗肿瘤活性分子 作用机制 研究进展 |
| 英文关键词: Wnt/β-catenin signaling pathway antitumor molecules mechanism of action research progress |
| 基金项目:海南省重点研发项目（ZDYF2021108）；海南省重大科技项目（ZDKJ202008，ZDKJ202018）；国家自然科学基金
项目（81973229，82160675）；广东省海洋药物重点实验室开放课题（LMM2021-4）；海南大学协同创新中心项目
（XTCX2022STB01） |
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| 中文摘要: |
| Wnt/β-catenin信号通路是一种在生物进化中具有高度保守性的信号传导途径，参与多
种生物学行为并产生重要作用，但该信号通路的异常激活也是引发多种癌症的原因之一，基于此
两种特点开发靶向Wnt/β-catenin通路的抗肿瘤药物是当前研究热点。本文介绍了Wnt/β-catnein
信号通路，并综述了2018—2021年靶向该信号通路的抗肿瘤活性小分子的生物学行为调控、作用
细胞及动物模型研究进展。 |
| 英文摘要: |
| The Wnt/β-catenin signaling pathway is a highly conservative signaling pathway in biological evolution. Nowadays, it
is well known that Wnt/β-catenin signaling is widely implicated in a variety of biological behaviors and its abnormal activation
contributes to the initiation and progression of various human cancers. Considering the above mentioned characteristics, it has be‑
come a topic of research for the antitumor molecules targeting Wnt/β-catenin signaling with greater efficacy and potential for
therapeutic benefits. The present review summarizes Wnt/β-catnein signaling pathway and its related antitumor small molecule
inhibitors reported during 2018 to 2021, highlighting the regulation mechanism, tested cell lines and xenograft models. |
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