| 吴美珠1,2
，周学明1,2*
，冯 硕1,2
，周金琪1,2
，楼永浩1,2.厚梗染木树化学成分的研究[J].海南师范大学学报自科版,2023,36(2):126-130 |
| 厚梗染木树化学成分的研究 |
| Study on Chemical Constituents of Saprosma crassipes |
| |
| DOI：10.12051/j.issn.1674-4942.2023.02.002 |
| 中文关键词: 染木树属 厚梗染木树 化学成分 环烯醚萜苷 甾体 蒽醌 |
| 英文关键词: Saprosma Saprosma crassipes chemical composition cyclic etherterpene glycosides steroids anthraquinone |
| 基金项目:国家自然科学基金项目（82260831） |
|
| 摘要点击次数: 375 |
| 全文下载次数: 339 |
| 中文摘要: |
| 为从染木树属（Saprosma）中获取更多有效的化合物，对中国特有的热带药用植物厚梗
染木树（Saprosma crassipes）中的化学成分进行分离纯化以及鉴定，增加染木树属化合物多样性。
综合利用正相硅胶柱层析、Sephadex LH-20凝胶柱层析、半制备HPLC等色谱分离技术，对该植物
的乙醇提取物进行系统的分离纯化；并运用NMR以及质谱鉴定技术鉴定化合物的结构。从厚梗染
木树中分离鉴定了 8 个化合物（1~8），包括 2 个环烯醚萜苷：车叶草苷（1）、去乙酰基车叶草苷酸
（2），1个蒽醌：1，3-二羟基-2-羟甲基蒽醌（3）以及5个甾体类化合物：卡基二醇（4）、9，11-脱氢麦
角甾醇过氧化物（5）、过氧化麦角甾醇（6）、羟基烯酮（7）和（3β）-柱头-5，25-二烯-3-醇（8）；所有化
合物均为首次从厚梗染木树中分离得到，化合物3~8为首次从染木树属中分离得到。 |
| 英文摘要: |
| In order to obtain more effective compounds from Saprosma, the chemical components of Saprosma crassipes, a
tropical medicinal plant endemic to China, were isolated, purified and identified to increase the diversity of compounds in
Saprosma crassipes. The ethanol extracts of the plant were systematically separated and purified by integrating normalphase silica gel column chromatography, Sephadex LH-20 gel column chromatography, and semi-prepared HPLC. The
NMR and mass spectrometry were used to identify the structure of compounds. Eight compounds (1-8) were isolated from
the stems of Saprosma crassipes, including two cyclic ether terpene glycosides asperuloside (1) and deacetyl asperulosidic
acid (2); one anthraquinone 1,3-dihydroxy-2-hydroxymethylanthraquinone(3), and five steroids kakidiol (4), 9,11-dehydro‑
ergosterol peroxide (5), ergosterol peroxide (6), hydroxyenone (7), and (3β) -stigma-5, 25-dien-3-ol (8). All compounds
were isolated for the first time from Saprosma crassipes, and the compounds 3-8 were isolated for the first time from the ge‑
nus Saprosma. |
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