| Eleven compounds were isolated by silica gel chromatography, Sephadex LH-20 chromatography, high perfor⁃
mance liquid chromatography and other technologies from Noni juice. The structures of these compounds were identified by
1D and 2D NMR. The compounds were identified to be blumenol A (1), (6R, 7E)-9-hydroxy-4,7-megastigmadien-3-one
(2), 4-allyl-2-hydroxyphenyl 1-O-β-D-apiosyl-(1→6)-β-D-glucopyranoside (3), 2-methoxy-4-vinylphenyl β-D-apio⁃
furanosyl-(1→6)-β-D-glucopyranoside (4), 4-hydroxyphenethyl-2′-R-hydroxypropanoate (5), 3-(3-hydroxy-4-methoxy⁃
phenyl) acrylic acid (6), trans-4-hydroxy cinnamic acid (7), methyl 3-(4-hydroxyphenyl) propionate (8), p-hydroxy-phen⁃
ylpropionic acid (9), homovanillyl alcohol (10), 4-hydroxy-3-methoxy benzoic acid (11). Compounds 1~2 and 5~11 were
isolated from Noni Juice for the first time. The antibacterial activities of all compounds were determined by microdilution
method. Compound 2 showed potential inhibitory activity against Bacillus cereus, with the MIC value of 2.5 µg/mL, while the MIC values of other compounds were all greater than 20 µg/mL. |
