| 唐 琳，郝梦菲，李 敢，丁丰泽，李 巧，王恩举*.基于聚集诱导发光的甲醛荧光探针[J].海南师范大学学报自科版,2021,34(1):8-11 |
| 基于聚集诱导发光的甲醛荧光探针 |
| Fluorescence Probe for FormaldehydeBased on Aggregation-induced Emission |
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| DOI：10.12051/j.issn.1674-4942.2021.01.002 |
| 中文关键词: 荧光探针 聚集诱导发光增强 甲醛 胺醛缩合 |
| 英文关键词: fluorescent probe aggregation-induced emission enhancement formaldehyde aldehyde-amine condensation |
| 基金项目:海南省大学生创新训练计划项目 |
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| 中文摘要: |
| 甲醛能使DNA受损，引起肝肾功能障碍，并最终导致恶性肿瘤，被世界卫生组织确定
为一类致癌物，因此，非常有必要开发能快速、方便检测甲醛的方法。本研究通过缩合4-二苯胺基
苯甲醛与对硝基苯乙腈，再还原硝基合成了一个能选择性检测甲醛的荧光探针（PAN）。PAN具有
聚集诱导发光性能，在含水体积分数为80%以上的乙腈/水中能产生明亮的绿色荧光。在含水体积
分数为70%的乙腈/水中，PAN的荧光很弱，加入甲醛能迅速发生胺醛缩合反应并产生聚集诱导荧
光，发出明亮的绿色荧光。其它所选7种常见含活性羰基的化合物都不能引起探针的发射光谱发
生明显变化，总之，该探针具有较好的灵敏性、选择性，且具有一定的实用价值。 |
| 英文摘要: |
| Formaldehyde can cause DNA damage, which induces liver and kidney dysfunction and eventually leads to can‐
cers. It has been categorized as a class I carcinogen by the World Health Organization. Thus, the fast and convenient meth‐
ods for detecting formaldehyde are significant for public health. Herein, a fluorescent probe (PAN) for formaldehyde was de‐
veloped by incorporating 4-(diphenylamino)benzaldehyde and 4-nitrophenylacetonitrile and then reducing the nitro-group.
The probe exhibits aggregation-induced emission enhancement (AIEE) characteristics and can produce bight green fluores‐
cence in an acetonitrile/water mixture when the volume fraction of water is over 80%. In acetonitrile/water mixture when the
volume fraction of water is 70%, PAN is well dispersed and emits weak fluorescence, but the addition of formaldehyde gives
anaggregation-induced emission enhancement. The other 7 selected active carbonyl compounds did not cause noticeable
fluorescence variations. In brief, PAN shows good sensitivity, selectivity and practicality. |
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