| 王天山，何春刚，文俏慧，刘沛铭，杨 媚.苯甲酸型芳香小分子的电喷雾多级质谱裂解规律[J].海南师范大学学报自科版,2020,33(1):36-43 |
| 苯甲酸型芳香小分子的电喷雾多级质谱裂解规律 |
| Fragmentation Study of Benzoic Acid Type Small AromaticMolecules by ESI-MSn |
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| DOI：10.12051/j.issn.1674-4942.2020.01.008 |
| 中文关键词: 芳香小分子 苯甲酸 电喷雾多级质谱 裂解规律 |
| 英文关键词: small aromatic molecules benzoic acid electrospray ionization tandem mass spectrometry fragmentation
pathway |
| 基金项目:教育部创新团队项目（IRT-16R19） |
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| 中文摘要: |
| 采用电喷雾多级质谱技术研究11种苯甲酸型芳香小分子化合物的裂解途径，解释苯
环上取代基的一般裂解规律。对所有的化合物均同时采用正离子和负离子检测模式进行扫描，取 ［M+H］+和［M-H］-
准分子离子峰进行多级碰撞诱导解离，通过分析母离子和碎片离子的关系来确
定这些化合物的裂解途径。研究结果表明，苯甲酸型芳香小分子优先断裂脱去主要的官能团，再
断裂苯环上的羟基和甲氧基，最后是苯环的裂解。 |
| 英文摘要: |
| Eleven benzoic acid type small aromatic molecules were introduced to analyze the fragmentation pathways by
electrospray ionization tandem mass spectrometry (ESI-MSn
), aiming at the investigation of fragmentation of functional
groups and substituted groups in benzene ring. Base on the ESI-MSn (n=1-4) analysis, the fragmentation patterns of all
compounds were proposed in positive-ion and negative-ion modes. The [M+H]+ and [M-H]- ions were readily observed in
conventional single-stage mass spectrometry, which were selected for collision-induced dissociation (CID) to produce
daughter ions. The ESI-MSn fragmentation pathways of small aromatic molecules were comprehensively elucidated, which
indicated the sequence of cleavages of functional groups, followed by neutral losses of substituted groups and ring-reducing
reaction in benzene ring. |
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