| 况家才，赵 婷，张 斌，余章昕，陈光英*.诺丽酵素的化学成分及其抗菌活性研究[J].海南师范大学学报自科版,2022,35(4):386-391 |
| 诺丽酵素的化学成分及其抗菌活性研究 |
| Study on Chemical Constituents and AntibacterialActivity of the Noni Juice |
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| DOI： |
| 中文关键词: 诺丽酵素 化学成分 酚类化合物 抗菌活性 |
| 英文关键词: noni juice chemical constituents phenolic compounds antibacterial activity |
| 基金项目:海南省高等学校科学研究项目（Hnky2021-30）；海南省重点研发项目（ZDYF2019165）；海南省院士创新平台科
研专项项目（YSPTZX202030）；中央引导地方科技发展资金项目（ZY2022HN08） |
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| 摘要点击次数: 2553 |
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| 中文摘要: |
| 运用硅胶柱层析、Sephadex LH-20、高效液相色谱等技术对诺丽酵素中化学成分进行
研究，从中分离得到11个化合物，运用 NMR 技术鉴定所得化合物的结构分别为blumenol A（1）、
（6R，7E）-9-hydroxy-4，7-megastigmadien-3-one（2）、4-allyl-2-hydroxyphenyl 1-O-β-D-apiosyl-（1
→6）- β -D-glucopyranoside （3）、2-methoxy-4-vinylphenyl β -D-apiofuranosyl-（1→6）- β -Dglucopyranoside（4）、4-hydroxyphenethyl-2′-R-hydroxypropanoate（5）、3-羟基-4-甲氧基肉桂酸
（6）、trans-4-hydroxy cinnamic acid（7）、对羟基苯丙酸甲酯（8）、p-hydroxy-phenylpropionic acid（9）、
3-甲氧基-4-羟基苯乙醇（10）、香草酸（11），化合物1~2及5~11为首次从诺丽酵素中分离得到。采
用微量稀释法测定全部化合物的抗菌活性，化合物2对蜡状芽孢杆菌显示出较好的抑制活性（MIC
值为2.5 µg/mL），其他化合物未显示明显抗菌活性（MIC值>20 µg/mL）。 |
| 英文摘要: |
| Eleven compounds were isolated by silica gel chromatography, Sephadex LH-20 chromatography, high perfor⁃
mance liquid chromatography and other technologies from Noni juice. The structures of these compounds were identified by
1D and 2D NMR. The compounds were identified to be blumenol A (1), (6R, 7E)-9-hydroxy-4,7-megastigmadien-3-one
(2), 4-allyl-2-hydroxyphenyl 1-O-β-D-apiosyl-(1→6)-β-D-glucopyranoside (3), 2-methoxy-4-vinylphenyl β-D-apio⁃
furanosyl-(1→6)-β-D-glucopyranoside (4), 4-hydroxyphenethyl-2′-R-hydroxypropanoate (5), 3-(3-hydroxy-4-methoxy⁃
phenyl) acrylic acid (6), trans-4-hydroxy cinnamic acid (7), methyl 3-(4-hydroxyphenyl) propionate (8), p-hydroxy-phen⁃
ylpropionic acid (9), homovanillyl alcohol (10), 4-hydroxy-3-methoxy benzoic acid (11). Compounds 1~2 and 5~11 were
isolated from Noni Juice for the first time. The antibacterial activities of all compounds were determined by microdilution
method. Compound 2 showed potential inhibitory activity against Bacillus cereus, with the MIC value of 2.5 µg/mL, while the MIC values of other compounds were all greater than 20 µg/mL. |
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