| 文丽君,王英,李海霞,李娟.5, 6-二甲基-2, 3-吡嗪二甲酰胺-钴配合物的合成及其抗菌活性研究[J].海南师范大学学报自科版,2016,29(3):300-303 |
| 5, 6-二甲基-2, 3-吡嗪二甲酰胺-钴配合物的合成及其抗菌活性研究 |
| Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3- pyrazinedimethylformamide-Co |
| 投稿时间：2016-04-12 |
| DOI：10.12051/j.issn.1674-4942.2016.03.20160314 |
| 中文关键词: 5, 6-二甲基-2, 3-吡嗪二甲酰胺-钴 配合物 合成 抗菌活性 |
| 英文关键词: 5,6-dimethyl-2,3- pyrazinedimethylformamide-Co complex synthesis antibacterial activity |
| 基金项目:海南医学院科研培育基金项目（HY2013-23）；海南省自然科学基金项目（20152040） |
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| 中文摘要: |
| 文章以2，3-二甲基-5，6-二氰基吡嗪为原料，在稀碱条件下由H2O2不完全氧化得到配体5, 6-二甲基-2, 3-吡嗪二甲酰胺，再与醋酸钴在弱碱条件下合成了5, 6-二甲基-2, 3-吡嗪二甲酰胺-钴.通过紫外光谱、红外光谱、差热-热重分析及元素分析进行表征，并利用牛津杯法预试验及试管二倍稀释法测定二甲基-2, 3-吡嗪二甲酰胺及其配合物对金黄色葡萄球菌、大肠埃希菌和白假丝酵母菌的抗菌活性. 结果表明，相对于配体5, 6-二甲基-2, 3-吡嗪二甲酰胺，5, 6-二甲基-2, 3-吡嗪二甲酰胺-钴配合物产生了新的活性，具有较好的抑菌杀菌作用，为临床疾病的治疗和食品添加剂的研发提供借鉴. |
| 英文摘要: |
| 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Co was prepared from Co（CH3COO）2 and 5,6-dimethyl-2,3-pyrazinedimethylformamide which was synthesized via hydrolysis of 2，3-dimethyl-5,6-pyrazinecarbonitrile in the dilute basic solution using H2O2 as the oxidant; The antibacterial activity of 5，6-dimethyl-2,3- pyrazinedimethylformamide and the complex were compared by the Oxford cup method and tube double dilution method; The complex was characterized by UV and IR spectrascopies, TGA and elemental analysis. The 5,6-dimethyl-2,3-pyrazinedimethylformamide-Co shows bacterio⁃static and bactericidal effect, but not obvious inhibitory effect by 5,6-dimethyl-2,3-pyrazinedimethylformamide; Compare to ligand, the complex has new biological activity, providing a reference for the clinical treatment of diseases and the development of food additives. |
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